反应详情

82 mg (0.2 mmol) of crude 1-benzyloxy-2-chloro-4-[2,2,2-trifluoro-1-(4-methoxy-benzyloxy)-1-trifluoromethyl-ethyl]-benzene were treated with 3 mL of a mixture of dichloromethane/trifluoroacetic acid (1:3) at room temperature for 1 h. The solvent was evaporated and the residue was redissolved in a mixture of diethyl ether and a solution of Na2CO3. The inorganic phase was extracted with diethyl ether and the combined organic phases were washed with brine and dried (Na2SO4). After filtration and evaporation of the solvent, the crude product was purified by column chromatography to give 7.3 mg (12%) of 2-(4-benzyloxy-3-chloro-phenyl)-1,1,1,3,3,3-hexafluoro-propan-2-ol as a yellow gum, MS: 383 (M−H, 1Cl)−.

1. customThe solvent was evaporated
2. dissolutionthe residue was redissolved in a mixture of diethyl ether
3. extractionThe inorganic phase was extracted with diethyl ether
4. washthe combined organic phases were washed with brine
5. dry with materialdried (Na2SO4)
6. filtrationAfter filtration and evaporation of the solvent
7. customthe crude product was purified by column chromatography