Iodoethane → HCID 21938545, compound

HRID 1453181Notes

Reaction equation

HRID 1453181 reaction equation
ICC.Br[CH:5]([CH2:10][CH3:11])[C:6](OC)=O.BrC1C=C(Cl)C(O)=C(Cl)C=1.[Br:22][C:23]1[CH:28]=[CH:27][C:26]([OH:29])=[C:25]([F:30])[CH:24]=1>>[Br:22][C:23]1[CH:28]=[CH:27][C:26]([O:29][CH2:6][CH:5]2[CH2:11][CH2:10]2)=[C:25]([F:30])[CH:24]=1

Participants

5

Reactant 4

HCID 6340IodoethaneHCID 185874-Bromo-2,6-dichlorophenolHCID 95577Butanoic acid, 2-bromo-, methyl esterHCID 27249814-Bromo-2-fluorophenol

Product 1

HCID 21938545HCID 21938545, compound

Procedure

The title compound was prepared analogously to Step 1 in Example A(52), where iodoethane was substituted instead of methyl α-bromobutyrate and 4-Bromo-2,6-dichloro-phenol was substituted instead of 4-Bromo-2-fluorophenol of that example. 1H NMR (CDCl3) δ 0.32-0.42 (m, 2H), 0.62-0.68 (m, 2H), 1.23-1.33 (m, 1H), 3.85 (d, J=6.9 Hz, 2H), 6.82 (t, J=8.8 Hz, 1H), 7.14-7.18 (m, 1H), 7.23 (dd, J=10.5, 2.3 Hz, 1H). ESIMS (MH+): 246.1.

Sources & evidence

ORD record
ord-4063e5a2cc5a46248bd8a4b4ba8e3290
Source dataset
uspto-grants-2009_01
Patent number
US07473790B2

Reaction notes

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