反应详情

Nitrogen gas was bubbled through a solution of methyl 3-benzyloxy-5-(4-fluorobenzyl)-4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate (37 mg, 0.09 mmol) in MeOH. To the solution was added a small amount of 10% Pd on carbon, and the mixture was stirred under an atmosphere of hydrogen gas overnight. The reaction mixture was filtered through celite, and the filter cake was washed with MeOH. The resulting filtrate was concentrated in vacuo to afford the title compound as a white solid. 1H NMR (400 MHz, d6-DMSO) δ 9.20 (s, 1H), 7.41-7.37 (m, 2H), 7.21-7.16 (m, 2H), 4.65 (s, 2H), 4.32 (t, J=6.0 Hz, 2H), 3.79 (s, 3H), 3.69 (t, J=6.0H, 2H). HRMS (FT-ICR) C15H14FN3O4+H=320.1047; calculated 320.1041.

1. filtrationThe reaction mixture was filtered through celite
2. washthe filter cake was washed with MeOH
3. concentrationThe resulting filtrate was concentrated in vacuo