Morpholine, 4-(chloroacetyl)- → HCID 68895558, compound

HRID 1453860Notes

Reaction equation

HRID 1453860 reaction equation
[CH2:1]([O:8][C:9]1[C:10]([C:19]([O:21][CH3:22])=[O:20])=[N:11][N:12]2[CH2:17][CH2:16][NH:15][C:14](=[O:18])[C:13]=12)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[CH2:24][C:25]([N:27]1[CH2:32][CH2:31][O:30][CH2:29][CH2:28]1)=[O:26]>>[CH2:1]([O:8][C:9]1[C:10]([C:19]([O:21][CH3:22])=[O:20])=[N:11][N:12]2[CH2:17][CH2:16][N:15]([CH2:24][C:25]([N:27]3[CH2:32][CH2:31][O:30][CH2:29][CH2:28]3)=[O:26])[C:14](=[O:18])[C:13]=12)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 74040Morpholine, 4-(chloroacetyl)-HCID 57528498HCID 57528498, compound

Product 1

HCID 68895558HCID 68895558, compound

Procedure

The title compound was prepared from methyl 3-benzyloxy-4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate using a procedure similar to Example 13, Step 1, except that 4-(2-chloroacetyl)morpholine was used in place of iodomethane. 1H NMR (400 MHz, CDCl3) δ 7.53-7.50 (d, 2H), 7.37-7.28 (m, 3H), 5.31-5.30 (m, 3H), 4.49-4.46 (t, 2H), 4.41 (s, 2H), 3.93 (s, 3H), 3.88-3.84 (t, 2H), 3.77-3.71 (m, 3H), 3.65-3.62 (t, 2H), 3.55-3.52 (t, 2H); ES MS (M+1)=429.

Sources & evidence

ORD record
ord-308fc8d566c744b5a23e4e83a8a3c218
Source dataset
uspto-grants-2009_01
Patent number
US07476666B2

Reaction notes

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