反应详情

The title compound was prepared following the procedure described in Example 18 from 4-hydroxy indole (10 mg; 0.075 mmol) and 3-(3-bromo-4,5-dimethoxyphenyl)-propenal (20 mg; 0.074) using morpholine (7 μl) as a base in refluxing methanol (0.6 ml) (yield: 33% ). 1H NMR (acetone-d6): 10.16 (s, 1H), 7.20 (d, J=3.0 Hz) and 7.19 (d, J=2.5 Hz) (1H), 7.02 (broad d, J=2.0 Hz), 6.97 (broad signal) and 6.93 (d, J=1.8 Hz) (2H), 6.89 and 6.88 (d each, J =8.4 Hz; 1H), 6.49 (d, J=8.8 Hz), 6.47-6.48 (m) and 6.44 (d, J=8.4 Hz) (2H), 6.18 (d, J=6.8 Hz) and 6.10 (d, J=4.5 Hz) (1H), 5.68-5.71 and 5.56-5.62 (m each, 1H), 4.33-4.38 (broad dd, J=5.8, 9.9 Hz; 1H), 3.83, 3.81 and 3.79 (s each, 6H), 2.41 (ddd, J=2.0, 6.1, 12.9 Hz) and 2.08-2.26 (m) (2H).