反应详情

(2S,3S)-3-(2-Aminophenylthio)-2-hydroxy-3-(4-methoxyphenyl)-N-phenylpropionamide (582 mg) is mixed with chlorobenzene (10 ml), and the mixture is refluxed for 25 hours during which thereto is added p-toluenesulfonic acid monohydrate (112 mg) in 8 portions (14 mg×8) at intervals of three hours. The reaction mixture is cooled to room temperature, and concentrated under reduced pressure to remove the chlorobenzene. To the residue is added methanol (5 ml), and the mixture is refluxed for one hour. The mixture is allowed to cool to room temperature, and stirred to crystallization, and then cooled with ice. The precipitated crystals are collected by filtration, washed with chilled methanol, and dried at 50° C. to give (2S,3S)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one (243 mg).

1. temperaturethe mixture is refluxed for 25 hours during which
2. concentrationconcentrated under reduced pressure
3. customto remove the chlorobenzene
4. additionTo the residue is added methanol (5 ml)
5. temperaturethe mixture is refluxed for one hour
6. temperatureto cool to room temperature
7. temperaturecooled with ice
8. filtrationThe precipitated crystals are collected by filtration
9. washwashed with chilled methanol
10. customdried at 50° C.