反应详情

A tetrahydrofuran (THF) (20 ml) containing 2.4 g of (2-amino-4-methoxy-6-tert-butylphenoxy)methoxymethane and 1.09 ml of phenyl isocyanate was stirred at room temperature for 3 hours, and then the solvent was removed under reduced pressure. The obtained residue was crystallized from hexane, and recrystallized from an ethyl acetate-hexane mixed solution to give 2.3 g of [2-(3-phenylureido)-4-methoxy-6-tert-butylphenoxy]methoxymethane (yield: 64%, melting point: 121°-123° C., IR: 3300, 1650 cm31 1).

1. customthe solvent was removed under reduced pressure
2. customThe obtained residue was crystallized from hexane
3. customrecrystallized from an ethyl acetate-hexane mixed solution