反应详情

19.8 g (60 mmol) of 4-(cis-4-tert-butylcyclohexylamino)-5-chloro-6-(1-chloroethyl)pyrimidine and 4.2 g (60 mmol) of sodium methanethiolate were heated at reflux in 100 ml of methanol for 6 hours. The mixture was concentrated and the residue was taken up in water/toluene. The organic phase was dried and concentrated, to give 17.7 g (85% of theory) of a colorless resin which was subsequently reacted without further purification.

1. concentrationThe mixture was concentrated
2. customThe organic phase was dried
3. concentrationconcentrated
4. customto give 17.7 g (85% of theory) of a colorless resin which
5. customwas subsequently reacted without further purification