Propyl mercaptan → (Propyldithio)ethylamidosuccinic acid

HRID 1460045Notes

Reaction equation

HRID 1460045 reaction equation
CO[C:3]([S:5][S:6][CH2:7][C:8]([NH:10][CH:11]([CH2:15][C:16]([OH:18])=[O:17])[C:12]([OH:14])=[O:13])=[O:9])=O.[CH2:19](S)[CH2:20]C>CO>[CH2:3]([S:5][S:6][CH2:7][C:8]([NH:10][CH:11]([CH2:15][C:16]([OH:18])=[O:17])[C:12]([OH:14])=[O:13])=[O:9])[CH2:19][CH3:20]

Participants

4

Reactant 2

HCID 7848Propyl mercaptanHCID 53797889(Methoxycarbonyldithio)ethylamidosuccinic acid

Product 1

HCID 54299494(Propyldithio)ethylamidosuccinic acid

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Conditions

Temperature
0 °C

Procedure

A flask was charged with 400 mg (1 eq., 1.5 mmole) of (methoxycarbonyldithio)ethylamidosuccinic acid dissolved in 5 ml methanol, cooled to 0° C., purged with argon, and then treated dropwise with a solution of 135.3 ml (114 mg, 1 eq., 1.5 mmole) propanethiol (purchased from Aldrich) in 4 ml of methanol over a 30 min. period. The reaction was then allowed to warm to room temperature and stirred for 18 hours. The volatiles were then removed by vacuum transfer and the residue applied to a flash silica gel column, eluting with 10% methanol/methylene chloride. 1H NMR (d6DMSO/TMS) δ: 0.92 (3H, t, CH3), 1.61 (2H, m, CH2), 2.30 (2H, m, CH2), 2.39 (2H, m, CH2), 2.69 (2H, m, 2× CH2), 3.31 (2H, m, 2× CH2), 8.03 (1H, t, NH), 12.05 (1H, br. s, CO2H). 13C NMR (d6DMSO/TMS) δ: 173.65 (Q), 170.97 (Q), 39.83 (CH2), 38.00 (CH2), 37.10 (CH2), 29.88 (CH2), 28.99 (CH2), 21.74 (CH2), 12.67 (CH3. 1H NMR (CD3OD/TMS) δ: 0.98 (3H, t, J=7.33 Hz, CH3), 1.69 (2H, h, J=7.22 Hz, CH2), 2.47 (2H, m with fine splitting, CH2), 2.56 (2H, m with fine splitting, CH2), 2.68 (2H, t, J=7.15 Hz, CH2), 2.77 (2H, t, J=6.84 Hz, CH2), 3.46 (2H, t, J=6.84 Hz, CH2). 13C NMR (CD3OD/TMS) δ: 176.72 (Q), 174.75 (Q), 41.87 (CH2), 39.87 (CH2), 38.42 (CH2), 31.77 (CH2), 30.72 (CH2), 23.47 (CH2), 13.40 (CH3).

Workup

  1. custompurged with argon
  2. temperatureto warm to room temperature
  3. customThe volatiles were then removed by vacuum transfer
  4. washeluting with 10% methanol/methylene chloride

Sources & evidence

ORD record
ord-1b1b715c1bce407a9a8861235ba2a958
Source dataset
uspto-grants-1998_12
Patent number
US05854409

Reaction notes

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