反应详情

In an analogous manner to that described in Example 3, a mixture of 3.8 g of 3-ethoxy-2-heptylacrolein, 4.7 g of trans-4-pentylcyclohexanecarboxamidine hydrochloride and 40 ml of absolute methanol is treated with a sodium methylate solution prepared from 0.8 g of sodium in 25 ml of absolute methanol. The reaction duration, working-up and chromatography are as described in Example 3. The pure fractions eluted in the chromatography are combined and recrystallised twice from acetonitrile at about -20° C. There is obtained analytically pure trans-2-(4-pentylcyclohexyl)-5-heptylpyrimidine; m.p. 22° C., cl.p. 40.5° C. (smectic).

1. washThe pure fractions eluted in the chromatography
2. customrecrystallised twice from acetonitrile at about -20° C