反应详情

In an analogous manner to that described in Example 3, a mixture of 6.3 g of 3-ethoxy-2-(p-butylphenyl)acrolein, 6.6 g of trans-4-pentylcyclohexanecarboxamidine hydrochloride and 60 ml of absolute methanol is treated with a sodium methylate solution prepared from 1.1 g of sodium in 25 ml of absolute methanol. The reaction duration, working-up and chromatography are as described in Example 3. The pure fractions (in accordance with thin-layer chromatography) resulting in the chromatography are combined and recrystallized twice from hexane. There is obtained analytically pure trans-2-(4-pentylcyclohexyl)-5-(p-butylphenyl)pyrimidine; m.p. 87° C., smectic-nematic phase transition 136.5° C., cl.p. 146.5° C.

1. customThe pure fractions (in accordance with thin-layer chromatography) resulting in the chromatography
2. customrecrystallized twice from hexane