反应详情

In an analogous manner to that described in Example 3, a mixture of 3.2 g of 3-methoxy-2-(trans-4-propylcyclohexyl)acrolein, 4.1 g of trans-4-pentylcyclohexanecarboxamidine hydrochloride and 50 ml of absolute methanol is treated with a sodium methylate solution prepared from 0.53 g of sodium in 20 ml of absolute methanol. The reaction duration, working-up and chromatography are as described in Example 3. The pure fractions (in accordance with thin-layer chromatography) resulting in the chromatography are combined and recrystallized twice from hexane. There is obtained pure 5-(trans-4-propylcyclohexyl)-2-(trans-4-pentylcyclohexyl)pyrimidine; m.p. 98° C., cl.p. 178° C. (smectic).

1. customThe pure fractions (in accordance with thin-layer chromatography) resulting in the chromatography
2. customrecrystallized twice from hexane