反应详情

(E)-7-(2-methyl-5-nitrostyryl)thieno[3,2-d]pyrimidine-4-amine (0.3 g, 0.96 mmol) was dissolved in ethyl acetate (5 mL) and then SnCl2.2H2O (1 g, 4.81 mmol) and conc. HCl (0.5 mL) were added thereto, and the reaction mixture was stirred at room temperature for 18 hours. After the reaction was completed NH4OH solution was added thereto to pH 5. Then, anhydrous Na2CO3 was added thereto to pH 7. The reaction mixture was filtered with Celite and washed with ethyl acetate several times. The filtrate was concentrated under reduced pressure to obtain the title compound (260 mg, 84% yield) without further purification.

1. additionwas added
2. filtrationThe reaction mixture was filtered with Celite
3. washwashed with ethyl acetate several times
4. concentrationThe filtrate was concentrated under reduced pressure