反应详情

温度

63 °C

A suspension of 2,2,2-trifluoro-N-methyl-N-(2-pyridin-3-yl-thiazol-5-yl)-acetamide (1.0 g, 3.5 mmol) and N-chlorosuccinimide (0.557 g, 4.2 mmol) in acetonitrile (30 mL) was heated to 63° C. under nitrogen for 3 h. The reaction mixture was cooled to room temperature and it was treated with additional N-chlorosuccinimide (0.557 g, 4.2 mmol) and heated to 35° C. under nitrogen for 2 h. The reaction mixture was cooled and concentrated under reduced pressure. The residue was redissolved in dichloromethane (80 mL) and washed with water (70 mL). The aqueous layer was re-extracted with methylene chloride (100 mL). The combined organic layers were washed with water (50 mL) and brine (50 mL), dried over sodium sulfate, filtered, concentrated under reduced pressure and purified using reverse phase chromatography. The product eluted with a gradient of acetonitrile in water. The desired product was isolated as a thick brown gum (0.337 g, 30%): 1H NMR (400 MHz, CDCl3) δ 9.12 (br, 1H), 8.75 (br, 1H), 8.22 (d, J=7.9 Hz, 1H), 7.28 (br, 1H), 3.40 (s, 3H); 19F NMR (376 MHz, CDCl3) δ−69.3; ESIMS m/z 324.3 (M+2); IR (thin film) 1772 cm−1.

1. temperatureThe reaction mixture was cooled to room temperature
2. temperatureheated to 35° C. under nitrogen for 2 h
3. temperatureThe reaction mixture was cooled
4. concentrationconcentrated under reduced pressure
5. dissolutionThe residue was redissolved in dichloromethane (80 mL)
6. washwashed with water (70 mL)
7. extractionThe aqueous layer was re-extracted with methylene chloride (100 mL)
8. washThe combined organic layers were washed with water (50 mL) and brine (50 mL)
9. dry with materialdried over sodium sulfate
10. filtrationfiltered
11. concentrationconcentrated under reduced pressure
12. custompurified
13. washThe product eluted with a gradient of acetonitrile in water