反应详情

5.0 g of (S)-5,6,7,8-tetrahydro-6-amino-1-naphthol, 2.2 g of 2-(2-thienyl)ethyl methane-sulfonate, 4.8 g of sodium carbonate and 100 ml of xylene were mixed to form a mixture, and the mixture was refluxed for 48 h to 50 h. The mixture was cooled to room temperature, and washed with an appropriate amount of water. Active carbon was added to decolorize the mixture. The mixture was filtered and left standing. An organic phase was reserved and concentrated under vacuum to obtain a residue. The residue was purified by column chromatography to obtain 1.3 g of (S)-5,6,7,8-tetrahydro-6-[N,N-bis[(2-thienyl)ethyl]]amino-1-naphthol.

1. temperaturethe mixture was refluxed for 48 h to 50 h
2. washwashed with an appropriate amount of water
3. additionActive carbon was added
4. filtrationThe mixture was filtered
5. waitleft standing
6. concentrationconcentrated under vacuum
7. customto obtain a residue
8. customThe residue was purified by column chromatography