反应详情

(2R)-2-(((3-fluoro-6-(4-methylcyclohex-1-en-1-yl)pyridin-2-yl)methyl)amino)-3-methylbutan-1-ol was prepared according to Example 199, substituting 4-methylcyclohex-1-enylboronic acid for bicyclo[2.2.1]hept-2-en-2-ylboronic acid. (2R)-2-(((3-fluoro-6-(4-methylcyclohex-1-en-1-yl)pyridin-2-yl)methyl)amino)-3-methylbutan-1-ol was subjected to hydrogenation (H2 atmosphere, Pd/C catalyst) to provide the title compound. MS (ESI+) m/z 309 (M+H)+.