2-(Bromomethyl)-5-(trifluoromethyl)furan → HCID 71534519, compound

HRID 1473199Notes

Reaction equation

HRID 1473199 reaction equation
[C:1]([O:5][CH:6]([C:11]1[N:16]([CH3:17])[C:15](=[O:18])[C:14]2[NH:19][CH:20]=[CH:21][C:13]=2[C:12]=1[C:22]1[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][CH:23]=1)[C:7]([O:9]C)=[O:8])([CH3:4])([CH3:3])[CH3:2].Br[CH2:30][C:31]1[O:32][C:33]([C:36]([F:39])([F:38])[F:37])=[CH:34][CH:35]=1>>[C:1]([O:5][CH:6]([C:11]1[N:16]([CH3:17])[C:15](=[O:18])[C:14]2[N:19]([CH2:30][C:31]3[O:32][C:33]([C:36]([F:39])([F:38])[F:37])=[CH:34][CH:35]=3)[CH:20]=[CH:21][C:13]=2[C:12]=1[C:22]1[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][CH:23]=1)[C:7]([OH:9])=[O:8])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 27946052-(Bromomethyl)-5-(trifluoromethyl)furanHCID 89463134methyl 2-(tert-butoxy)-2-(4-(4-chlorophenyl)-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetate

Product 1

HCID 71534519HCID 71534519, compound

Procedure

The title compound was prepared in a manner similar to that described in Example 2 from methyl 2-(tert-butoxy)-2-(4-(4-chlorophenyl)-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetate and 2-(bromomethyl)-5-(trifluoromethyl)furan. 1H NMR (400 MHz, CHLOROFORM-d) ppm 7.51-7.61 (m, 1H) 7.39-7.47 (m, 2H) 7.32-7.39 (m, 1H) 7.08-7.15 (m, 1H) 6.65-6.73 (m, 1H) 6.43-6.51 (m, 1H) 5.94-6.00 (m, 1H) 5.75-5.91 (m, 2H) 5.26 (s, 1H) 3.63 (s, 3H) 0.96 (s, 9H); LC/MS (m/z) ES+=537 (M+1).

Sources & evidence

ORD record
ord-8f8541ba21a34469a11c988650366b26
Source dataset
uspto-grants-2015_04
Patent number
US09012642B2

Reaction notes

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