反应详情

The title compound was prepared in an analogous manner to that of EXAMPLE 525, except that 4-(4-chloro-2-methoxyphenyl)-N-(pyrimidin-4-yl)quinazoline-7-sulfonamide and (3-(trifluoromethyl)phenyl)boronic acid were used as the coupling partners to afford 4-(3-methoxy-3′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)-N-(pyrimidin-4-yl)quinazoline-7-sulfonamide as an off-white solid. 1H NMR (400 MHz, DMSO-d6) δ=9.48 (s, 1H), 8.58 (s, 1H), 8.50 (s, 1H), 8.23 (br. s., 1H), 8.19-8.11 (m, 2H), 8.10-8.01 (m, 1H), 7.89 (d, J=8.8 Hz, 1H), 7.85-7.72 (m, 2H), 7.62-7.53 (m, 3H), 7.01 (br. s., 1H), 3.82 (s, 6H). m/z (ESI) 538.2 (M+H)+.

1. customThe title compound was prepared in an analogous manner to that of EXAMPLE 525