2-Chlorobutylbutyrate → 1-(Butyryloxy)butyl-5-amino-4-oxopentanoate Hydrochloride

HRID 1474571Notes

Reaction equation

HRID 1474571 reaction equation
[Cl:1][CH:2]([CH2:10][CH3:11])[CH2:3][O:4][C:5](=[O:9])[CH2:6][CH2:7][CH3:8].C(OC([NH:19][CH2:20][C:21](=[O:27])[CH2:22][CH2:23][C:24]([OH:26])=[O:25])=O)(C)(C)C>>[ClH:1].[C:5]([O:4][CH:3]([O:26][C:24](=[O:25])[CH2:23][CH2:22][C:21](=[O:27])[CH2:20][NH2:19])[CH2:2][CH2:10][CH3:11])(=[O:9])[CH2:6][CH2:7][CH3:8]

Participants

3

Reactant 2

HCID 150943452-ChlorobutylbutyrateHCID 179898205-((tert-Butoxycarbonyl)amino)-4-oxopentanoic acid

Product 1

HCID 867092051-(Butyryloxy)butyl-5-amino-4-oxopentanoate Hydrochloride

Procedure

The compound was prepared as described in Procedures A and B above from 2-chlorobutylbutyrate and 5-(tert-butoxycarbonylamino)-4-oxopentanoic acid. 1H-NMR (300 MHz, CD3OD) ppm δ 0.95+0.96 (two t, J=6.6 Hz, 6H, two Me), 1.65 (m, 6H, CH3CH2CH2CO2+CH3CH2CH2CH), 2.27 (t, J=10.8 Hz, 2H, CH2CH2CH2CO2), 2.70 (“t”, 2H, COCH2CH2CO2), 2.87 (“t”, 2H, COCH2CH2CO2), 4.02 (s, 2H, CH2NH2), 6.72 (t, J=8.4 Hz, 1H, OCHO).

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-96b4af036c6d4a1d95eca331bb254bf4
Source dataset
uspto-grants-2015_04
Patent number
US09018257B2

Reaction notes

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