反应详情

To a solution of 1-(4-bromophenyl)cyclopropane carboxylic acid (3.0 g, 12.4 mmol) in dry THF (40 mL) under nitrogen atmosphere, was added borane dimethyl sulphide (8.83 mL, 19.8 mmol, 2 M solution in DCM) at 0° C. The reaction mixture was stirred at r.t for 4 h. After the completion of reaction as confirmed by TLC, the reaction mixture was quenched by dropwise addition of methanol until effervescence stopped. Volatiles were evaporated in vacuo and the compound was diluted with ethyl acetate (80 mL). The organic layer was separated; washed with water (3×10 mL), dried over Na2SO4 and concentrated. The crude product obtained was purified by column chromatography (silica gel, 1:4 EtOAc:Pet Ether) to afford title compound (2.7 g, 96%) as a solid.

1. customAfter the completion of reaction
2. customthe reaction mixture was quenched by dropwise addition of methanol until effervescence
3. customVolatiles were evaporated in vacuo
4. additionthe compound was diluted with ethyl acetate (80 mL)
5. customThe organic layer was separated
6. washwashed with water (3×10 mL)
7. dry with materialdried over Na2SO4
8. concentrationconcentrated
9. customThe crude product obtained
10. customwas purified by column chromatography (silica gel, 1:4 EtOAc:Pet Ether)