反应详情

温度

50 °C

Methyl 8-(4-((tert-butoxycarbonylamino)methyl)-3-fluorophenyl)-1-cyclopropyl-9-methyl-4-oxo-4H-quinolizine-3-carboxylate (24 mg, 0.050 mmol) was dissolved in MeOH (2 mL) and 1M aqueous sodium hydroxide (0.5 mL, 0.5 mmol) was added. The mixture was stirred at 50° C. for 2 h. After cooling, the MeOH was removed in vacuum and the residue was dissolved in water (5 mL) and neutralized with 1M HCl (˜0.5 mL). The precipitate formed was extracted with DCM (3×4 mL). The organic layer was concentrated to afford the title compound as a yellow solid (20 mg, 86%).

1. temperatureAfter cooling
2. customthe MeOH was removed in vacuum
3. dissolutionthe residue was dissolved in water (5 mL)
4. customThe precipitate formed
5. extractionwas extracted with DCM (3×4 mL)
6. concentrationThe organic layer was concentrated