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HRID1478375

反应详情

EQUATION

反应方程式

HRID 1478375 的结构方程式

REACTANTS

反应物

2
结构：CC(C)(C)OC(=O)N1CCc2cc(B3OC(C)(C)C(C)(C)O3)ccc21
HCID18451469

tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-indole-1-carboxylate

C19H28BNO4

结构：COC(=O)c1cc(C2CC2)c2c(C)c(Cl)ccn2c1=O
HCID86696543

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)c1cc(C2CC2)c2c(C)c(-c3ccc4c(c3)CCN4C(=O)OC(C)(C)C)ccn2c1=O
HCID86696772

未命名化合物

收率 99%

PROCEDURE

实验过程

Methyl 8-(1-(tert-butoxycarbonyl)indolin-5-yl)-1-cyclopropyl-9-methyl-4-oxo-4H-quinolizine-3-carboxylate was prepared according to General Procedure A from methyl 8-chloro-1-cyclopropyl-9-methyl-4-oxo-4H-quinolizine-3-carboxylate (75 mg, 0.26 mmol) and tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indoline-1-carboxylate (106.4 mg, 0.31 mmol). Purification by flash silica column chromatography (DCM:MeOH) (1:0 to 9:1) afforded the title compound as a yellow solid (121 mg, 99%).

WORKUP

后处理

  1. customMethyl 8-(1-(tert-butoxycarbonyl)indolin-5-yl)-1-cyclopropyl-9-methyl-4-oxo-4H-quinolizine-3-carboxylate was prepared
  2. customPurification by flash silica column chromatography (DCM:MeOH) (1:0 to 9:1)