反应详情

(1R,3E)-1-Cyclopropylpent-3-en-1-ol (C24) was converted to the product according to the method used for the synthesis of ({[(2R)-2-(2,2-diethoxyethoxyl)pent-4-en-1-yl]oxy}methyl)benzene (C2) in Preparation P1, except that all reagents were combined at 0° C. The product was obtained as a colorless oil. Yield: 550 mg, 2.27 mmol, 48%. 1H NMR (400 MHz, CDCl3) δ 5.44-5.59 (m, 2H), 4.62 (dd, J=5.3, 5.3 Hz, 1H), 3.66-3.76 (m, 3H), 3.54-3.63 (m, 2H), 3.47 (dd, J=10.3, 5.5 Hz, 1H), 2.65 (dt, J=8.5, 5.9 Hz, 1H), 2.28-2.33 (m, 2H), 1.65-1.68 (m, 3H), 1.23 (t, J=7.1 Hz, 3H), 1.23 (t, J=7.0 Hz, 3H), 0.79-0.88 (m, 1H), 0.53-0.60 (m, 1H), 0.42-0.50 (m, 1H), 0.34-0.41 (m, 1H), 0.06-0.13 (m, 1H).

1. customwere combined at 0° C
2. customThe product was obtained as a colorless oil