反应详情

The mixture of epimers was synthesized in analogy to Example 63b, using 5-Cyclopropyl-4-((R)-2,2,2-trifluoro-1-methyl-ethoxy)-pyridine-2-carboxylic acid (Example 73a) and 1-Cyclopropyl-1-(5-methyl-[1,2,4]oxadiazol-3-yl)-ethylamine (CAN 1155536-64-3) as starting materials and isolated (135 mg, 70%) as light yellow oil. The mixture of epimers was separated by preparative chiral HPLC (Chiralpak AD, isopropanol/heptane) and the title compound was the first epimer collected and isolated as colorless oil; MS (ESI, m/z): 425.5 (M+H+).

1. additionThe mixture of epimers
2. customwas synthesized in analogy to Example 63b
3. customisolated (135 mg, 70%) as light yellow oil
4. additionThe mixture of epimers
5. customwas separated by preparative chiral HPLC (Chiralpak AD, isopropanol/heptane)
6. customcollected
7. customisolated as colorless oil