反应详情

The title compound was synthesized in analogy to Example 112e, using 5-(1-fluorocyclobutyl)-4-(2,2,2-trifluoroethoxy)pyridine-2-carboxylic acid (example 285a) and 1-Cyclopropyl-1-(5-methyl-[1,2,4]oxadiazol-3-yl)-ethylamine (CAN 1155536-64-3) as starting materials and the racemate was separated into its enantiomers by preparative chiral HPLC (Chiralpak AD, ethanol/heptane). The title compound was the first enantiomer collected; MS (ESI, m/z): 443.3 (M+H+).

1. customthe racemate was separated into its enantiomers by preparative chiral HPLC (Chiralpak AD, ethanol/heptane)
2. customcollected