反应详情

The title compound was prepared according to Example 40 using N-(2-methoxy-6-(methylsulfonyl)pyridin-3-yl)formamide (Preparation 73) and 2-(methylsulfonyl)-N-neopentylpyrido[3,4-d]pyrimidin-8-amine (Preparation 47). The residue was purified by silica gel column chromatography eluting with 50-100% EtOAc in cyclohexane. The residue was dissolved in EtOAc and washed with HCl (0.5 M, 10 mL), dried (MgSO4) and concentrated in vacuo. The residue was triturated with DCM and dried under vacuum to give the title compound (3 mg, 6%).

1. customThe title compound was prepared
2. customThe residue was purified by silica gel column chromatography
3. washeluting with 50-100% EtOAc in cyclohexane
4. dissolutionThe residue was dissolved in EtOAc
5. washwashed with HCl (0.5 M, 10 mL)
6. dry with materialdried (MgSO4)
7. concentrationconcentrated in vacuo
8. customThe residue was triturated with DCM
9. customdried under vacuum