HCID 89996011, compound → HCID 73386780, compound

HRID 1480774Notes

Reaction equation

HRID 1480774 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([C:9]2[N:13]([CH3:14])[CH:12]=[N:11][CH:10]=2)[CH:6]=[CH:5][C:4]=1[NH:15][CH:16]=O.CS(C1[N:23]=[CH:24][C:25]2[CH:31]=[CH:30][N:29]=[C:28]([NH:32][CH2:33][C:34]([CH3:37])([CH3:36])[CH3:35])[C:26]=2[N:27]=1)(=O)=O>>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([C:9]2[N:13]([CH3:14])[CH:12]=[N:11][CH:10]=2)[CH:6]=[CH:5][C:4]=1[NH:15][C:16]1[N:23]=[CH:24][C:25]2[CH:31]=[CH:30][N:29]=[C:28]([NH:32][CH2:33][C:34]([CH3:37])([CH3:36])[CH3:35])[C:26]=2[N:27]=1

Participants

3

Reactant 2

HCID 89996011HCID 89996011, compoundHCID 89996126HCID 89996126, compound

Product 1

HCID 73386780HCID 73386780, compoundYield 38%

Procedure

The title compound was prepared according to Example 40 using N-(2-methoxy-4-(1-methyl-1H-imidazol-5-yl)phenyl)formamide (Preparation 74) and 2-(methylsulfonyl)-N-neopentylpyrido[3,4-d]pyrimidin-8-amine (Preparation 47). The residue was purified by silica gel column chromatography eluting with 0-20% MeOH in EtOAc followed by a second chromatography eluting with 0-10% MeOH in EtOAc to give the title compound (7.5 mg, 38%).

Workup

  1. customThe title compound was prepared
  2. customThe residue was purified by silica gel column chromatography
  3. washeluting with 0-20% MeOH in EtOAc
  4. washeluting with 0-10% MeOH in EtOAc

Sources & evidence

ORD record
ord-8eb478537b7c4bb389e3c3ba69d2fcf7
Source dataset
uspto-grants-2016_08
Patent number
US09409907B2

Reaction notes

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