反应详情

温度

150 °C

A mixture of 1-(5-fluoro-pyridin-3-yl)-4-hydroxy-7-phenoxy-isoquinoline-3-carboxylic acid methyl ester (51 mg, 0.13 mmol), 3-amino-2,2-dimethyl-propionic acid TFA salt (121 mg, 0.52 mmol) and NaOMe (56 mg, 1.05 mmol) in EtOH (3 mL) was heated at 150° C. in a microwave reactor for 6 h. The solvent was evaporated, and the residue was partitioned between water (20 mL) and EtOAc (20 mL). 1 M HCl was added with vigorous stirring until pH was ˜3. The organic layer was dried over MgSO4 and concentrated. The crude product was purified by column chromatography (0-35% EtOAc/hexanes+2% AcOH) to give 30 mg of the title compound as a yellow solid. MS: (+) m/z 476.14 (M+1).

1. customThe solvent was evaporated
2. customthe residue was partitioned between water (20 mL) and EtOAc (20 mL)
3. addition1 M HCl was added
4. dry with materialThe organic layer was dried over MgSO4
5. concentrationconcentrated
6. customThe crude product was purified by column chromatography (0-35% EtOAc/hexanes+2% AcOH)