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HRID1481657

反应详情

EQUATION

反应方程式

HRID 1481657 的结构方程式

REACTANTS

反应物

3
结构：O=C(n1ccnc1)n1ccnc1
HCID68263

1,1'-Carbonylbis(1H-imidazole)

C7H6N4O

结构：Fc1cccc2c1CNC2
HCID14795867

4-Fluoro-2,3-dihydro-1H-isoindole

C8H8FN

结构：CC[C@@H]1CC(C)CC/C=C\[C@@H]2C[C@@]2(C(=O)NS(=O)(=O)C2(C)CC2)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@H]1NC(=O)OC(C)(C)C
HCID90127988

未命名化合物

PRODUCTS

生成物

1
结构：CC[C@@H]1CC(C)CC/C=C\[C@@H]2C[C@@]2(C(=O)NS(=O)(=O)C2(C)CC2)NC(=O)[C@@H]2C[C@@H](OC(=O)N3Cc4cccc(F)c4C3)CN2C(=O)[C@H]1NC(=O)OC(C)(C)C
HCID90148569

未命名化合物

PROCEDURE

实验过程

A solution of tert-butyl((2R,6S,7R,13aS,14aR,16aS,Z)-7-ethyl-2-hydroxy-9-methyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-6-yl)carbamate (0.062 g, 0.1 mmol) and CDI (0.019 g, 0.120 mmol) was stirred for 6 h. To the solution was added 4-fluoroisoindoline (0.018 g, 0.130 mmol), and then stirred overnight. Concentration gave 80 mg of a crude mixtures (2R,6S,7R,13aS,14aR,16aS,Z)-6-((tert-butoxycarbonyl)amino)-7-ethyl-9-methyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl 4-fluoroisoindoline-2-carboxylate, which was used as it was.

WORKUP

后处理

  1. concentrationConcentration