反应详情

(R)-tert-butyl 2-((2-amino-5-bromophenyl)ethynyl)pyrrolidine-1-carboxylate (4.32 g) was prepared via Sonogashira coupling according to the general procedure described in Example 156, Step 1, from 4-bromo-2-iodoaniline (3.96 g, 13.29 mmol) and (R)-tert-butyl 2-ethynylpyrrolidine-1-carboxylate (3.25 g, 16.64 mmol) in 89% yield.