反应详情

Prepared in 43% yield from methyl(2S)-2-(tert-butoxy)-2-[(22S)-4,17,18,22,28-pentamethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18,24-undecaen-3-yl]acetate following the procedure for methyl(2S)-2-(tert-butoxy)-2-[(22S)-18-fluoro-4,22,28-trimethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18-decaen-3-yl]acetate. 1H NMR (400 MHz, CDCl3) δ 8.16 (d, J=8.0 Hz, 1H), 8.13 (s, 1H), 8.02 (s, 1H), 7.51 (t, J=7.7 Hz, 1H), 7.35-7.30 (m, 2H), 7.15 (s, 1H), 6.82 (s, 1H), 6.05 (br. s., 1H), 4.55 (br. s., 1H), 3.93 (t, J=10.9 Hz, 1H), 3.77 (t, J=11.0 Hz, 1H), 3.69 (s, 3H), 3.54-3.43 (m, 2H), 3.10 (d, J=11.3 Hz, 1H), 2.69 (d, J=9.8 Hz, 1H), 2.45 (s, 3H), 2.32 (s, 3H), 2.26 (s, 3H), 1.99-1.70 (m, 10H), 1.28 (s, 3H), 1.25 (s, 9H), 1.15 (d, J=6.0 Hz, 3H); LCMS (ESI, M+1): 668.35.