反应详情

Prepared in 100% yield from methyl(2S)-2-(tert-butoxy)-2-[(22S)-17-fluoro-4,18,22,28-tetramethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18-decaen-3-yl]acetate following the procedure for (2S)-2-(tert-butoxy)-2-[(22S)-18-fluoro-4,22,28-trimethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18,24-undecaen-3-yl]acetic acid. 1H NMR (600 MHz, DMSO-d6) δ 8.15 (s, 1H), 8.05 (d, J=7.3 Hz, 1H), 7.96 (s, 1H), 7.50 (t, J=7.7 Hz, 1H), 7.31 (d, J=7.7 Hz, 1H), 7.15 (t, J=5.0 Hz, 2H), 7.09 (d, J=6.6 Hz, 1H), 5.64 (br. s., 1H), 4.62 (br. s., 1H), 3.95-3.13 (m, 5H), 2.67 (d, J=9.2 Hz, 1H), 2.40 (s, 3H), 2.29 (s, 3H), 2.00-1.53 (m, 10H), 1.20 (s, 3H), 1.13 (s, 9H), 1.08 (d, J=5.5 Hz, 3H); LCMS (ESI, M): 657.4.