反应详情

Prepared in 95% yield from methyl(2S)-2-(tert-butoxy)-2-[(22S,24E)-19-fluoro-4,22,28-trimethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18,24-undecaen-3-yl]acetate following the procedure for (2S)-2-(tert-butoxy)-2-[(22S)-8-chloro-4,17,22,28-tetramethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18-decaen-3-yl]acetic acid. 1H NMR (500 MHz, DMSO-d6) δ 8.01 (s, 1H), 7.99 (d, J=7.7 Hz, 1H), 7.95 (s, 1H), 7.56 (t, J=7.5 Hz, 1H), 7.40 (d, J=7.7 Hz, 1H), 7.33-7.24 (m, 2H), 7.21 (dd, J=8.1, 5.1 Hz, 1H), 7.17 (s, 1H), 6.14 (dt, J=14.4, 7.3 Hz, 1H), 5.78 (d, J=14.7 Hz, 1H), 5.73 (br. s., 1H), 4.36 (br. s., 1H), 4.09 (t, J=11.0 Hz, 1H), 4.01-3.92 (m, 2H), 3.64-3.41 (m, 2H), 2.69 (d, J=10.6 Hz, 1H), 2.41 (s, 3H), 2.14-2.05 (m, 1H), 1.99-1.89 (m, 2H), 1.72-1.67 (m, 3H), 1.25 (s, 3H), 1.15 (s, 9H), 0.80 (d, J=5.9 Hz, 3H); LCMS (ESI, M): 641.3.