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HRID1482074

反应详情

EQUATION

反应方程式

HRID 1482074 的结构方程式

REACTANTS

反应物

2
结构：COC(=O)[C@@H](OC(C)(C)C)c1c(C)c(Br)c2nc3cn2c1N1CCC(C)(CC1)OCCCC[C@H](C)Oc1c(F)cccc1-c1cccc-3c1
HCID118316321

未命名化合物

结构：Cc1ccc2c(c1)-c1cccc(c1)-c1nc3cc(C)c([C@H](OC(C)(C)C)C(=O)O)c(n3c1Cl)N1CCC(C)(CC1)OCCCC[C@H](C)O2
HCID118332041

未命名化合物

PRODUCTS

生成物

1
结构：Cc1c([C@H](OC(C)(C)C)C(=O)O)c2n3cc(nc3c1Br)-c1cccc(c1)-c1cccc(F)c1O[C@@H](C)CCCCOC1(C)CCN2CC1
HCID118316320

未命名化合物

收率 5%

PROCEDURE

实验过程

Prepared in 5% yield from methyl(2S)-2-[(22S)-5-bromo-19-fluoro-4,22,28-trimethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18-decaen-3-yl]-2-(tert-butoxy)acetate following the procedure for (2S)-2-(tert-butoxy)-2-[(22S)-8-chloro-4,17,22,28-tetramethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18-decaen-3-yl]acetic acid. 1H NMR (500 MHz, DMSO-d6) δ 8.09 (s, 1H), 8.06 (s, 1H), 8.02 (d, J=7.7 Hz, 1H), 7.60 (t, J=7.7 Hz, 1H), 7.47 (d, J=7.7 Hz, 1H), 7.33-7.27 (m, 2H), 7.23-7.16 (m, 1H), 6.03 (br. s., 1H), 4.31 (br. s., 1H), 3.96-3.90 (m, 1H), 3.55 (t, J=11.2 Hz, 1H), 3.45 (br. s., 2H), 3.08 (d, J=8.4 Hz, 1H), 2.77 (br. s., 1H), 2.51 (s, 3H), 1.98-1.65 (m, 10H), 1.22 (s, 3H), 1.18 (s, 9H), 0.77 (d, J=5.9 Hz, 3H); LCMS (ESI, M): 721.3.