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HRID1482085

反应详情

EQUATION

反应方程式

HRID 1482085 的结构方程式

REACTANTS

反应物

2
结构：COC(=O)[C@@H](OC(C)(C)C)c1c(C)c(C)c2nc3cn2c1N1CCC(C)(CC1)OCCCC[C@H](C)Oc1cc(F)c(F)cc1-c1cccc-3c1
HCID118316332

未命名化合物

结构：Cc1ccc2c(c1)-c1cccc(c1)-c1nc3cc(C)c([C@H](OC(C)(C)C)C(=O)O)c(n3c1Cl)N1CCC(C)(CC1)OCCCC[C@H](C)O2
HCID118332041

未命名化合物

PRODUCTS

生成物

1
结构：Cc1c([C@H](OC(C)(C)C)C(=O)O)c2n3cc(nc3c1C)-c1cccc(c1)-c1cc(F)c(F)cc1O[C@@H](C)CCCCOC1(C)CCN2CC1
HCID118316330

未命名化合物

收率 52.5%

PROCEDURE

实验过程

Prepared in 52.5% yield from methyl(2S)-2-(tert-butoxy)-2-[(22S)-17,18-difluoro-4,5,22,28-tetramethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18-decaen-3-yl]acetate following the procedure for (2S)-2-(tert-butoxy)-2-[(22S)-8-chloro-4,17,22,28-tetramethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18-decaen-3-yl]acetic acid. 1H NMR (500 MHz, DMSO-d6) δ 8.17 (d, J=7.7 Hz, 1H), 8.09 (s, 1H), 8.00 (s, 1H), 7.53 (t, J=7.7 Hz, 1H), 7.48-7.42 (m, 1H), 7.38-7.29 (m, 2H), 6.01 (br. s., 1H), 4.67 (br. s., 1H), 3.84 (t, J=11.0 Hz, 1H), 3.64 (t, J=11.6 Hz, 1H), 3.49-3.41 (m, 2H), 3.12 (d, J=7.7 Hz, 1H), 2.64 (d, J=9.2 Hz, 1H), 2.51 (s, 3H), 2.31 (s, 3H), 1.93-1.47 (m, 10H), 1.20 (s, 3H), 1.17 (s, 9H), 1.10 (d, J=5.9 Hz, 3H); LCMS (ESI, M): 675.3.