反应详情

Prepared in 17.2% yield from methyl(2S)-2-(tert-butoxy)-2-[(22S)-17,19-difluoro-4,5,22,28-tetramethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18-decaen-3-yl]acetate following the procedure for (2S)-2-(tert-butoxy)-2-[(22S)-8-chloro-4,17,22,28-tetramethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18-decaen-3-yl]acetic acid. 1H NMR (500 MHz, DMSO-d6) δ 8.07 (s, 1H), 8.03 (d, J=7.3 Hz, 1H), 7.94 (br. s., 1H), 7.57 (t, J=7.5 Hz, 1H), 7.46 (d, J=7.7 Hz, 1H), 7.34 (t, J=9.2 Hz, 1H), 7.19 (d, J=9.2 Hz, 1H), 6.04 (br. s., 1H), 4.20 (br. s., 1H), 3.92 (t, J=10.6 Hz, 1H), 3.55 (t, J=11.2 Hz, 1H), 3.41 (br. s., 4H), 2.48 (s, 3H), 2.31 (s, 3H), 1.93 (d, J=13.6 Hz, 1H), 1.88-1.79 (m, 2H), 1.69 (d, J=12.5 Hz, 5H), 1.54 (br. s., 2H), 1.20 (s, 3H), 1.17 (s, 9H), 0.73 (d, J=5.9 Hz, 3H); LCMS (ESI, M): 675.3.