反应详情

Prepared in 78% yield from methyl(2S)-2-(tert-butoxy)-2-[(22S)-16,17-difluoro-4,22,28-trimethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18-decaen-3-yl]acetate following the procedure for (2S)-2-(tert-butoxy)-2-[(22S)-8-chloro-4,17,22,28-tetramethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18-decaen-3-yl]acetic acid. 1H NMR (500 MHz, DMSO-d6) δ 8.08 (d, J=7.7 Hz, 1H), 7.97 (s, 1H), 7.88 (s, 1H), 7.54 (t, J=7.7 Hz, 1H), 7.42-7.35 (m, 1H), 7.32 (d, J=6.2 Hz, 1H), 7.29 (s, 1H), 6.99 (d, J=7.3 Hz, 1H), 5.89 (br. s., 1H), 4.62 (br. s., 1H), 3.92-3.81 (m, 1H), 3.61 (t, J=11.2 Hz, 1H), 3.46-3.41 (m, 2H), 3.12 (d, J=9.9 Hz, 1H), 2.64 (d, J=8.4 Hz, 1H), 2.40 (s, 3H), 1.93-1.50 (m, 10H), 1.19 (s, 3H), 1.16 (s, 9H), 1.07 (d, J=6.2 Hz, 3H); LCMS (ESI, M+): 661.3.