反应详情

Prepared in 25.8% yield from methyl(2S)-2-(tert-butoxy)-2-[(22S)-16,17-difluoro-4,5,22,28-tetramethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18-decaen-3-yl]acetate following the procedure for (2S)-2-(tert-butoxy)-2-[(22S)-8-chloro-4,17,22,28-tetramethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18-decaen-3-yl]acetic acid. 1H NMR (500 MHz, DMSO-d6) δ 8.14 (d, J=8.1 Hz, 1H), 7.97 (s, 1H), 7.87 (s, 1H), 7.53 (t, J=7.7 Hz, 1H), 7.38 (q, J=9.4 Hz, 1H), 7.31 (d, J=7.7 Hz, 1H), 6.99 (d, J=6.6 Hz, 1H), 5.92 (br. s., 1H), 4.62 (br. s., 1H), 3.86 (t, J=11.2 Hz, 1H), 3.58 (t, J=10.6 Hz, 1H), 3.44 (br. s., 4H), 2.48 (s, 3H), 2.30 (s, 3H), 1.92-1.79 (m, 3H), 1.77-1.58 (m, 7H), 1.18 (s, 3H), 1.15 (s, 9H), 1.07 (d, J=5.9 Hz, 3H); LCMS (ESI, M): 675.3.