反应详情

Prepared in 25.9% yield from methyl(2S)-2-(tert-butoxy)-2-[(22S)-16,17-difluoro-5-(1-hydroxyethyl)-4,22,28-trimethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18-decaen-3-yl]acetate following the procedure for (2S)-2-(tert-butoxy)-2-[(22S)-8-chloro-4,17,22,28-tetramethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18-decaen-3-yl]acetic acid. 1H NMR (500 MHz, DMSO-d6) δ 8.08 (d, J=7.7 Hz, 1H), 7.98 (s, 1H), 7.90 (s, 1H), 7.56 (t, J=7.7 Hz, 1H), 7.39 (q, J=9.4 Hz, 1H), 7.34 (d, J=7.0 Hz, 1H), 7.00 (d, J=7.7 Hz, 1H), 5.97 (br. s., 1H), 5.50 (br. s., 1H), 4.62 (br. s., 1H), 3.89-3.83 (m, 1H), 3.60 (t, J=11.0 Hz, 1H), 3.42-3.34 (m, 2H), 3.15 (d, J=8.4 Hz, 1H), 2.64 (br. s., 1H), 2.41 (s, 3H), 1.92-1.82 (m, 2H), 1.77-1.58 (m, 8H), 1.51 (d, J=6.6 Hz, 3H), 1.19 (s, 3H), 1.17 (s, 9H), 1.07 (d, J=5.9 Hz, 3H); LCMS (ESI, M+1): 706.10.