反应详情

Prepared in 54.4% yield from methyl(2S)-2-(tert-butoxy)-2-[(22S)-5-cyano-17-fluoro-4,22,28-trimethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18-decaen-3-yl]acetate following the procedure for (2S)-2-(tert-butoxy)-2-[(22S)-8-chloro-4,17,22,28-tetramethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18-decaen-3-yl]acetic acid. 1H NMR (500 MHz, DMSO-d6) δ 8.19 (s, 1H), 8.15-8.08 (m, 2H), 7.57 (t, J=7.7 Hz, 1H), 7.40 (d, J=7.3 Hz, 1H), 7.22 (d, J=9.5 Hz, 1H), 7.16 (d, J=5.5 Hz, 2H), 5.86 (br. s., 1H), 4.61 (br. s., 1H), 3.81 (t, J=12.3 Hz, 1H), 3.61 (t, J=11.4 Hz, 1H), 3.43 (br. s., 3H), 3.23-3.15 (m, 1H), 2.73 (br. s., 1H), 2.63 (s, 3H), 1.96-1.60 (m, 9H), 1.53 (br. s., 1H), 1.20 (s, 3H), 1.17 (s, 9H), 1.06 (d, J=5.9 Hz, 3H); LCMS (ESI, M+1): 669.3.