反应详情

A suspension of 2-[4-methyl-3-(trifluoromethoxy)phenoxy]-5-nitropyridine (Intermediate 30, 594 mg, 1.89 mmol) and Pd/C 5% w/w (40 mg) in THF (3 mL) was hydrogenated under 5 bar of H2, at 35° C. for 18 hrs. The mixture was filtered to remove the catalyst, diluted with ethyl acetate (10 mL) and washed with an aqueous 13% solution of NaCl (10 mL). The organic layer, dried over Na2SO4, was evaporated to give the title compound (475 mg) as brown oil.

1. filtrationThe mixture was filtered
2. customto remove the catalyst
3. additiondiluted with ethyl acetate (10 mL)
4. washwashed with an aqueous 13% solution of NaCl (10 mL)
5. dry with materialThe organic layer, dried over Na2SO4
6. customwas evaporated