反应详情

The title compound was obtained according to the procedure described for the synthesis of Example 14 (Step 2), starting from 1-benzhydryl-5-iodo-pyrimidine-2,4-dione (0.81 g, 2 mmol) and 3-pyridylboronic acid (0.370 g, 3 mmol). The crude was purified by column chromatography using a Teledyne ISCO apparatus (cyclohexane:EtOAc 30:70) to afford the title compound (0.17 g, 24%) as a white solid. 1H NMR (400 MHz, CDCl3): δ 7.14 (s, 1H), 7.20-7.24 (m, 4H), 7.29-7.33 (m, 2H), 7.36-7.46 (m, 6H), 7.93 (dt, J=8.1, 2.0 Hz, 1H), 8.41 (d, J=1.7 Hz, 1H), 8.45 (s, 1H), 8.52 (dd, J=4.9, 1.6 Hz, 1H). MS (ESI) m/z: 356 [M-H]+.

1. customdescribed for the synthesis of Example 14 (Step 2)
2. customThe crude was purified by column chromatography