Benzaldehyde, 2-methoxy-5-nitro- → 1-(5-Amino-2-methoxy-benzyl)-piperidine-4-carboxylic acid tert-butylamide

HRID 1486705Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1486705
COC1C=CC([N+]([O-])=O)=CC=1C=O.C(NC(C1CCNCC1)=O)(C)(C)C.[C:27]([NH:31][C:32]([CH:34]1[CH2:39][CH2:38][N:37]([CH2:40][C:41]2[CH:46]=[C:45]([N+:47]([O-])=O)[CH:44]=[CH:43][C:42]=2[O:50][CH3:51])[CH2:36][CH2:35]1)=[O:33])([CH3:30])([CH3:29])[CH3:28]>>[C:27]([NH:31][C:32]([CH:34]1[CH2:39][CH2:38][N:37]([CH2:40][C:41]2[CH:46]=[C:45]([NH2:47])[CH:44]=[CH:43][C:42]=2[O:50][CH3:51])[CH2:36][CH2:35]1)=[O:33])([CH3:30])([CH3:29])[CH3:28]

Komponenten

4

Edukt 3

HCID 90685Benzaldehyde, 2-methoxy-5-nitro-HCID 7175833N-tert-butylpiperidine-4-carboxamideHCID 867065381-(2-Methoxy-5-nitro-benzyl)-piperidine-4-carboxylic acid tert-butylamide

Produkt 1

HCID 867065371-(5-Amino-2-methoxy-benzyl)-piperidine-4-carboxylic acid tert-butylamide

Versuchsvorschrift

The title compound is prepared according to the reactions described for BB-5 above starting from 2-methoxy-5-nitro-benzaldehyde and piperidine-4-carboxylic acid tert-butylamide yielding after reductive amination 1-(2-methoxy-5-nitro-benzyl)-piperidine-4-carboxylic acid tert-butylamide; LC-MS A: tR=0.61 min; [M+H]+=350.18 followed by reduction with stannous chloride the title compound; LC-MS A: tR=0.42 min; [M+H]+=320.24.

Aufarbeitung

  1. customThe title compound is prepared

Quellen und Nachweise

ORD-Eintrag
ord-2b4386689c9f48caa2b91615ed48b037
Quelldatensatz
uspto-grants-2016_08
Patentnummer
US09428456B2

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