反应详情

温度

20 °C

Into a 100-mL round-bottom flask, was placed 2-(4-methoxytetrahydro-2H-pyran-4-yl)-4-(trifluoromethyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole (compound 217.1, 1.3 g, 3.42 mmol), trifluoroacetic acid (4 mL), Et3SiH (2 mL). The resulting solution was stirred overnight at 20° C., then quenched by the addition of 20 mL of water. The pH of the solution was adjusted to 8 with sodium hydroxide (1 M). The aqueous phase was extracted with 2×100 mL of ethyl acetate. The combined organic layers were washed with 2×50 mL of brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure. This resulted in 1 g (crude) of the title compound as a light yellow oil.

1. customInto a 100-mL round-bottom flask, was placed
2. customquenched by the addition of 20 mL of water
3. extractionThe aqueous phase was extracted with 2×100 mL of ethyl acetate
4. washThe combined organic layers were washed with 2×50 mL of brine
5. dry with materialdried over anhydrous sodium sulfate
6. concentrationconcentrated under reduced pressure