HRID1490217

反应详情

EQUATION

反应方程式

REACTANTS

反应物

反应SMILES：O=C1CCN(CC23CC(c4ccccc42)c2ccccc23)CC1

HCID21480605

未命名化合物

反应SMILES：CC(C)(C)[Si](C)(C)OCc1cncc(Br)c1

HCID21984091

3-Bromo-5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridine

C12H20BrNOSi

PRODUCTS

产物

反应SMILES：CC(C)(C)[Si](C)(C)OCc1cncc(C2(O)CCN(CC34CC(c5ccccc53)c3ccccc34)CC2)c1

HCID21480638

未命名化合物

收率 62%

PROCEDURE

实验过程

Using a procedure similar to that described in example 1 except starting with 1-(9,10-dihydro-9,10-methanoanthracen-9-ylmethyl)-4-piperidinone (described in example 5d) and employing 3-bromo-5-(tert-butyldimethylsilyl)oxymethylpyridine (described in example 69b), the title compound was formed in 62% yield as an oil. TLC analysis (Rf 0.25, 30% ethyl acetate in hexane). MS (CI, CH4) m/z 527 (M+1,100), 555 (M+29,14), 509 (20),395 (20)

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-50c564206002423aa7d10a802cfedd1a
来源数据集: uspto-grants-1997_10
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US05681840
来源说明: uspto-grants-1997_10

反应SMILES

[CH:1]1[C:14]2[C:13]3([CH2:16][N:17]4[CH2:22][CH2:21][C:20](=[O:23])[CH2:19][CH2:18]4)[CH2:15][CH:6]([C:7]4[C:12]3=[CH:11][CH:10]=[CH:9][CH:8]=4)[C:5]=2[CH:4]=[CH:3][CH:2]=1.Br[C:25]1[CH:26]=[N:27][CH:28]=[C:29]([CH2:31][O:32][Si:33]([C:36]([CH3:39])([CH3:38])[CH3:37])([CH3:35])[CH3:34])[CH:30]=1>>[Si:33]([O:32][CH2:31][C:29]1[CH:30]=[C:25]([C:20]2([OH:23])[CH2:21][CH2:22][N:17]([CH2:16][C:13]34[CH2:15][CH:6]([C:7]5[CH:8]=[CH:9][CH:10]=[CH:11][C:12]=53)[C:5]3[C:14]4=[CH:1][CH:2]=[CH:3][CH:4]=3)[CH2:18][CH2:19]2)[CH:26]=[N:27][CH:28]=1)([C:36]([CH3:39])([CH3:38])[CH3:37])([CH3:35])[CH3:34]