反应详情

The methyl 6-[2,6-difluoro-4-(methoxymethyl)phenyl]-5-fluoropyridine-2-carboxylate was treated with THF (2 mL), MeOH (2 mL) and 1.0 M aq. NaOH (2 mL, 2 mmol) at room temperature for 1 h. The volatile solvents were removed under reduced pressure. The residue was neutralized to pH around 5-6 with 1N HCl. The solids that precipitated were collected by filtration, rinsed with water, and dried to give the sub-title compound as a white solid (374 mg, 98.2%). LCMS calc. for C14H11F3NO3 (M+H)+ m/z=298.1. found: 298.0.

1. customThe volatile solvents were removed under reduced pressure
2. customThe solids that precipitated
3. filtrationwere collected by filtration
4. washrinsed with water
5. customdried