huagongshe.com
HRID1501950

反应详情

EQUATION

反应方程式

HRID 1501950 的结构方程式

REACTANTS

反应物

4
结构：CC(C)(C)OC(=O)N1CCN[C@@H](CO)C1
HCID24820286

tert-Butyl (3R)-3-(hydroxymethyl)piperazine-1-carboxylate

C10H20N2O3

结构：C[C@@H]1Cc2cc(Br)ccc2C(=O)O1
HCID71270763

未命名化合物

结构：C[C@@H]1Cc2cc([C@@H]3CN4CCN(C(=O)OC(C)(C)C)C[C@H]4CO3)ccc2C(=O)O1
HCID71273516

未命名化合物

结构：C[C@@H]1Cc2cc([C@H]3CN4CCN(C(=O)OC(C)(C)C)C[C@H]4CO3)ccc2C(=O)O1
HCID71273517

未命名化合物

PRODUCTS

生成物

1
结构：C[C@@H]1Cc2cc([C@H]3CN4CCN(C(=O)OC(C)(C)C)C[C@@H]4CO3)ccc2C(=O)O1
HCID86727033

未命名化合物

PROCEDURE

实验过程

8G and 8H were prepared in a similar manner as 8A and 8B except (3R)-6-Bromo-3-methyl-3,4-dihydro-1H-isochromen-1-one and tert-butyl (3R)-3-(hydroxymethyl)piperazine-1-carboxylate were used as the starting materials. The cis/trans mixture was purified via chiral HPLC (20% 2:1 MeOH:MeCN/CO2) on OJ column. The slower eluting diastereomer was the trans isomer: 8G LC-MS: (M+1)+403; 8H: LC-MS: (M+1)+403.

WORKUP

后处理

  1. customThe cis/trans mixture was purified via chiral HPLC (20% 2:1 MeOH:MeCN/CO2) on OJ column
  2. washThe slower eluting diastereomer