反应详情

Into a THF (10 mL) solution of 4-benzyloxy-1-{4-[2-(1-piperidinyl)ethoxy]phenyl}-1H-pyridin-2-one (Example 2, 130 mg, 0.32 mmol), 10% palladium-on-carbon (165 mg) was added and stirred at room temperature for 10 hours in hydrogen atmosphere. The reaction liquid was filtered, washed thoroughly with methanol, and the filtrate was concentrated under reduced pressure. THF was added to the resulting residue and the formed precipitate was recovered by filtration and dried to provide the title compound (75 mg, 74%).

1. customThe reaction liquid
2. filtrationwas filtered
3. washwashed thoroughly with methanol
4. concentrationthe filtrate was concentrated under reduced pressure
5. additionTHF was added to the resulting residue
6. filtrationthe formed precipitate was recovered by filtration
7. customdried