反应详情

Pyridine-3-carbaldehyde(0.076 ml) was added to a 1,2-dichloroethane solution(3 ml) of 1-methyl-6-{5-[(pyridin-3-ylmethyl)-amino]-pentyloxy}-1H-quinolin-2-one(237 mg). The mixture was stirred for 30 minutes at room temperature. Sodium triacetoxyborohydride(0.23 g) was added to the mixture, and the mixture was stirred at room temperature for 3 days. A saturated sodium hydrogencarbonate aqueous solution was added to the reaction mixture, followed by extraction using dichloromethane. The organic layer was dried with anhydrous sodium sulfate, and condensed under reduced pressure. The residue was purified by NH silica gel column chromatography (ethyl acetate: hexane=1:1). The purified product was condensed under reduced pressure to give the title compound(247 mg) as a yellow oil.

1. stirringthe mixture was stirred at room temperature for 3 days
2. extractionfollowed by extraction
3. dry with materialThe organic layer was dried with anhydrous sodium sulfate, and condensed under reduced pressure
4. customThe residue was purified by NH silica gel column chromatography (ethyl acetate: hexane=1:1)
5. customcondensed under reduced pressure