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HRID1504758

反应详情

EQUATION

反应方程式

HRID 1504758 的结构方程式

REACTANTS

反应物

2
结构：Cc1nc(Nc2cc(N[C@@H]3CCCC[C@@H]3NC(=O)OC(C)(C)C)cnc2C(N)=O)ccc1O
HCID86731654

未命名化合物

结构：Cc1cc(Cl)cc(Nc2cc(N[C@@H]3CCCC[C@@H]3NC(=O)OC(C)(C)C)cnc2C#N)n1
HCID86731656

未命名化合物

PRODUCTS

生成物

1
结构：Cc1cc(O)cc(Nc2cc(N[C@@H]3CCCC[C@@H]3NC(=O)OC(C)(C)C)cnc2C(N)=O)n1
HCID178429073

未命名化合物

PROCEDURE

实验过程

This example describes the conversion of (D13) to (E15) as shown in Scheme 3. tert-butyl [(1S,2R)-2-({6-carbamoyl-5-[(4-hydroxy-6-methylpyridin-2-yl)amino]pyridin-3-yl}amino)cyclohexyl]carbamate was prepared from tert-butyl [(1S,2R)-2-({5-[(4-chloro-6-methylpyridin-2-yl)amino]-6-cyanopyridin-3-yl}amino)cyclohexyl]carbamate (PrepEx 1.7) using chemistry analogous to that described for the synthesis of tert-butyl [(1S,2R)-2-({6-carbamoyl-5-[(5-hydroxy-6-methylpyridin-2-yl)amino]pyridin-3-yl}amino)cyclohexyl]carbamate (PrepEx 1.9). MS ESI calc'd. for C23H33N6O4 [M+H]+ 457. found 457.